From adcb261bd65009850416d9bb88d8b0129ff7f996 Mon Sep 17 00:00:00 2001
From: Rui Ribeiro <rui.ribeiro@icloud.com>
Date: Thu, 10 Mar 2022 11:26:56 +0100
Subject: [PATCH] pre-release

---
 .ipynb_checkpoints/SSBtoolkit-Tutorial1-checkpoint.ipynb  | 2 +-
 .ipynb_checkpoints/SSBtoolkit-Tutorial2-checkpoint.ipynb  | 2 +-
 .ipynb_checkpoints/SSBtoolkit-Tutorial3A-checkpoint.ipynb | 2 +-
 .../SSBtoolkit-Tutorial3B-tauRAMD-checkpoint.ipynb        | 2 +-
 README.md                                                 | 8 ++++----
 SSBtoolkit-Tutorial1.ipynb                                | 2 +-
 SSBtoolkit-Tutorial2.ipynb                                | 2 +-
 SSBtoolkit-Tutorial3A.ipynb                               | 2 +-
 SSBtoolkit-Tutorial3B-tauRAMD.ipynb                       | 2 +-
 9 files changed, 12 insertions(+), 12 deletions(-)

diff --git a/.ipynb_checkpoints/SSBtoolkit-Tutorial1-checkpoint.ipynb b/.ipynb_checkpoints/SSBtoolkit-Tutorial1-checkpoint.ipynb
index d93b89b..feef343 100644
--- a/.ipynb_checkpoints/SSBtoolkit-Tutorial1-checkpoint.ipynb
+++ b/.ipynb_checkpoints/SSBtoolkit-Tutorial1-checkpoint.ipynb
@@ -12,7 +12,7 @@
     "\n",
     "<br><br><br><br>\n",
     "\n",
-    "# Simulation of dose-response curves from affinity values\n",
+    "# Simulation of dose-response curves of agonists using affinity values\n",
     "\n",
     "In this tutorial we will simulate a mathematical model of a signaling pathway to obtain dose-response curves, from wich  *potency (EC<sub>50</sub>)* values of agonists can be infered. \n",
     "\n",
diff --git a/.ipynb_checkpoints/SSBtoolkit-Tutorial2-checkpoint.ipynb b/.ipynb_checkpoints/SSBtoolkit-Tutorial2-checkpoint.ipynb
index f71f5a6..0e10eb6 100644
--- a/.ipynb_checkpoints/SSBtoolkit-Tutorial2-checkpoint.ipynb
+++ b/.ipynb_checkpoints/SSBtoolkit-Tutorial2-checkpoint.ipynb
@@ -13,7 +13,7 @@
     "<br><br><br><br>\n",
     "<br>\n",
     "\n",
-    "# Simulation of dose-response curves of antagonists\n",
+    "# Simulation of dose-response curves of antagonists using affinity values\n",
     "\n",
     "In this tutorial we will simulate a mathematical model of a signaling pathway to obtain dose-response curves of antagonists, from wich their *potencies (IC$_{50}$)* can be infered. \n",
     "\n",
diff --git a/.ipynb_checkpoints/SSBtoolkit-Tutorial3A-checkpoint.ipynb b/.ipynb_checkpoints/SSBtoolkit-Tutorial3A-checkpoint.ipynb
index a752599..b4992fc 100644
--- a/.ipynb_checkpoints/SSBtoolkit-Tutorial3A-checkpoint.ipynb
+++ b/.ipynb_checkpoints/SSBtoolkit-Tutorial3A-checkpoint.ipynb
@@ -13,7 +13,7 @@
     "<br><br><br><br>\n",
     "<br>\n",
     "\n",
-    "# Simulation of  dose-response curves from kinetic values\n",
+    "# Simulation of  dose-response curves of agonists using kinetic values\n",
     "\n",
     "In this tutorial we will simulate mathematical model of a signaling pathway to obtain dose-response curves, and consequently, predict the *efficacy (EC$_{50}$)* of drugs. \n",
     "\n",
diff --git a/.ipynb_checkpoints/SSBtoolkit-Tutorial3B-tauRAMD-checkpoint.ipynb b/.ipynb_checkpoints/SSBtoolkit-Tutorial3B-tauRAMD-checkpoint.ipynb
index 7e01490..8bfe1aa 100644
--- a/.ipynb_checkpoints/SSBtoolkit-Tutorial3B-tauRAMD-checkpoint.ipynb
+++ b/.ipynb_checkpoints/SSBtoolkit-Tutorial3B-tauRAMD-checkpoint.ipynb
@@ -12,7 +12,7 @@
     "<br><br><br><br>\n",
     "<br>\n",
     "\n",
-    "# Simulation of dose-response cruves from data acquired with tauRAMD \n",
+    "# Simulation of dose-response cruves of agonsits using data acquired with tauRAMD \n",
     "\n",
     "\n",
     "In this notebook we will a simulate mathematical model of a signaling pathway to obtain dose-response curves using kinetic values obtained with the <b>tauRAMD</b> tool.\n",
diff --git a/README.md b/README.md
index d5855eb..0738923 100644
--- a/README.md
+++ b/README.md
@@ -25,10 +25,10 @@ What is about:
 
 How to do:
 
-1. [Simulation of dose-responses curves from affinity values](SSBtoolkit-Tutorial1.ipynb) 
-2. [Simulation of dose-responses curves of antagonists](SSBtoolkit-Tutorial2.ipynb)
-3. [Simulation of dose-responses curves from kenetic values](SSBtoolkit-Tutorial3A.ipynb)
-4. [Simulation of dose-response cruves from data acquired with tauRAMD ](SSBtoolkit-Tutorial3B-tauRAMD.ipynb)
+1. [Simulation of dose-response curves of agonists using affinity values](SSBtoolkit-Tutorial1.ipynb) 
+2. [Simulation of dose-response curves of antagonists using affinity values](SSBtoolkit-Tutorial2.ipynb)
+3. [Simulation of dose-response curves of agonists using kenetic values](SSBtoolkit-Tutorial3A.ipynb)
+4. [Simulation of dose-response curves of agonists using data acquired with tauRAMD](SSBtoolkit-Tutorial3B-tauRAMD.ipynb)
 5. [Exploring SSB pathways associated to disease variants](SSBtoolkit-Tutorial4-OXTR.ipynb)
 
 
diff --git a/SSBtoolkit-Tutorial1.ipynb b/SSBtoolkit-Tutorial1.ipynb
index d93b89b..feef343 100644
--- a/SSBtoolkit-Tutorial1.ipynb
+++ b/SSBtoolkit-Tutorial1.ipynb
@@ -12,7 +12,7 @@
     "\n",
     "<br><br><br><br>\n",
     "\n",
-    "# Simulation of dose-response curves from affinity values\n",
+    "# Simulation of dose-response curves of agonists using affinity values\n",
     "\n",
     "In this tutorial we will simulate a mathematical model of a signaling pathway to obtain dose-response curves, from wich  *potency (EC<sub>50</sub>)* values of agonists can be infered. \n",
     "\n",
diff --git a/SSBtoolkit-Tutorial2.ipynb b/SSBtoolkit-Tutorial2.ipynb
index f71f5a6..0e10eb6 100644
--- a/SSBtoolkit-Tutorial2.ipynb
+++ b/SSBtoolkit-Tutorial2.ipynb
@@ -13,7 +13,7 @@
     "<br><br><br><br>\n",
     "<br>\n",
     "\n",
-    "# Simulation of dose-response curves of antagonists\n",
+    "# Simulation of dose-response curves of antagonists using affinity values\n",
     "\n",
     "In this tutorial we will simulate a mathematical model of a signaling pathway to obtain dose-response curves of antagonists, from wich their *potencies (IC$_{50}$)* can be infered. \n",
     "\n",
diff --git a/SSBtoolkit-Tutorial3A.ipynb b/SSBtoolkit-Tutorial3A.ipynb
index a752599..b4992fc 100644
--- a/SSBtoolkit-Tutorial3A.ipynb
+++ b/SSBtoolkit-Tutorial3A.ipynb
@@ -13,7 +13,7 @@
     "<br><br><br><br>\n",
     "<br>\n",
     "\n",
-    "# Simulation of  dose-response curves from kinetic values\n",
+    "# Simulation of  dose-response curves of agonists using kinetic values\n",
     "\n",
     "In this tutorial we will simulate mathematical model of a signaling pathway to obtain dose-response curves, and consequently, predict the *efficacy (EC$_{50}$)* of drugs. \n",
     "\n",
diff --git a/SSBtoolkit-Tutorial3B-tauRAMD.ipynb b/SSBtoolkit-Tutorial3B-tauRAMD.ipynb
index 7e01490..8bfe1aa 100644
--- a/SSBtoolkit-Tutorial3B-tauRAMD.ipynb
+++ b/SSBtoolkit-Tutorial3B-tauRAMD.ipynb
@@ -12,7 +12,7 @@
     "<br><br><br><br>\n",
     "<br>\n",
     "\n",
-    "# Simulation of dose-response cruves from data acquired with tauRAMD \n",
+    "# Simulation of dose-response cruves of agonsits using data acquired with tauRAMD \n",
     "\n",
     "\n",
     "In this notebook we will a simulate mathematical model of a signaling pathway to obtain dose-response curves using kinetic values obtained with the <b>tauRAMD</b> tool.\n",
-- 
GitLab