OBJECTIVES

## Reconstruct and simulate data-driven scaffold models of brain and brain tissue

In coordination with the other parts of the HBP, we have four long-term objectives

- establish a generic strategy to reconstruct and simulate the multi-level organisation of the brain for different brain areas, whole brains and species;
- use this strategy to build high-fidelity reconstructions, first of the mouse brain and ultimately, of the human brain;
- support in silico experiments using the models;
- support community-driven reconstructions and simulations, and comparisons between models based on different tools and approaches.

#### Workflows and Use Cases

We provide tools and services that enable you to work through a number of pipelines; these are categorised by level of expertise and by their service maturity level.

#### Community driven

Results, methods and code are shared and made public to boost collaborative scientific advancements

#### Co-design

A co-design loop between science and engineering ensures the required substantial technical and scientific innovations

WORKFLOWS AND USE CASES

## Choose The Tools That Better Suit Your Needs

Interactive Workflows and Use Cases are selected procedures that guide the users through the resolution of realistic scientific problems. A dedicated Guidebook instructs the users on how to best exploit the utilities offered by the Platform.

- Grouped by topic
- Accessible via interactive panels
- Implemented as either Web Applications or Python Jupyter Notebooks

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Workflows/
Use Cases
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Jupyter
Notebooks
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Web
Applications
EXPLORE

MONITORS

## Visualize HPC systems available resources

- The HPC Status Monitor allows a real-time check of the availability status of the HPC systems accessible from the platform and provides an instant snapshot of the resource quotas available to the user on each system

LIVE PAPERS

## Live Papers

The "Live Papers" are highly interactive documents that give you access to the resources presented in recently published scientific articles related to the tools and services available on the Platform

An efficient analytical reduction of detailed nonlinear neuron models.
Nat. Commun.
Amsalem et al. 2020
Graph-theoretical Derivation of Brain Structural Connectivity.
Appl. Math. Comput.
Giacopelli et al. 2020
The microcircuits of striatum in silico.
PNAS
Hjorth et al. 2020
Computational modeling of inhibitory transsynaptic signaling in hippocampal and cortical neurons expressing intrabodies against gephyrin.
Front. Cell. Neurosci.
Lupascu et al. 2020
Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1.
Cell. Rep.
McCauley et al. 2020
Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage.
Commun. Biol.
Masoli et al. 2020
EXPLORE

TEAM

## Who We Are

CONTACTS

## Get In Touch

We are always happy to hear from users and to get feedback to improve the platform, tools and services we offer.

Drop us an email with your feedback or ask your questions by filling out the dedicated form.

### Follow Us On Social Media